Endocrine Abstracts

Introduction: A possible involvement of proteasomes in the pathogenesis of type II diabetes mellitus has been recently reported. Therefore, association of polymorphism of proteosomal genes with type II diabetes mellitus is of particular interest. In this study, molecular markers of the proteasomal alpha subunit 6 gene PSMA6 and its adjacent genomic sites have been analyzed.The goal of this study was to characterize polymorphisms of the HSMS801, HSMS702, ...

Introduction: Metformin improves hyperglycaemia via mechanisms which include activation of AMP-activated protein kinase (AMPK). Recent findings indicate that some metabolic actions of metformin occur also by AMPK-independent mechanisms.Objective: To study the action of metformin on expression of GLUT1 glucose transporter in rat models of severe and mild stretozotocin diabetes mellitus.Materials and methods: Severe diabetes mellitus...